PD-L1在乳腺癌中表達(dá)及臨床意義

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【摘要】目的：探究乳腺癌患者PD-L1表達(dá)及臨床意義。方法：選擇在我院進(jìn)行乳腺癌篩查的女性患者作為研究對(duì)象（時(shí)間2017年1月—2019年6月），原位癌15例、浸潤(rùn)癌35例、良性病變15例，對(duì)患者進(jìn)行免疫組織化學(xué)染色，比較患者PD-L1陽(yáng)性表達(dá)情況。結(jié)果：35例浸潤(rùn)癌患者PD-L1陽(yáng)性表達(dá)率57.14%（20/35），高于15例原位癌患者PD-L1陽(yáng)性表達(dá)率26.67%（4/15），差異顯著（P

【關(guān)鍵詞】乳腺癌；PD-L1；陽(yáng)性表達(dá)率

PD-L1 expression in breast cancer and its clinical significance

ZHANG Meifang， WU Dongen， HU Leilei， CHEN Zhifei

Department of Pathology，Maternal and Child Health Hospital of Heyuan City， Heyuan， Guangdong 517000， China

【Abstract】Objective：To explore the expression and clinical significance of PD-L1 in breast cancer patients.Methods：Selected female patients undergoing breast cancer screening in our hospital as the research object （time from January 2017 to June 2019），15 cases of carcinoma in situ，35 cases of invasive carcinoma，and 15 cases of benign lesions.The patients were examined by immunohistochemical staining to compare the positive expression of PD-L1 in patients.Results：The positive expression rate of PD-L1 in 35 patients with invasive carcinoma was 57.14%（20/35），which was higher than 26.67%（4/15）in 15 patients with carcinoma in situ，the difference was significant（P

【Key Words】Breast cancer； PD-L1； Positive expression rate

“乳腺癌”多發(fā)于外上象限乳房，是由于乳腺上皮細(xì)胞增殖失控引起的惡變，在女性惡性腫瘤中發(fā)病率最高，病因尚未完全清楚，存在遺傳風(fēng)險(xiǎn)。（剩余5718字）