熊去氧膽酸治療妊娠期肝內(nèi)膽汁淤積癥(ICP)的效果與妊娠結(jié)局觀察

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【摘要】目的：探究妊娠期肝內(nèi)膽汁淤積癥（ICP）采用熊去氧膽酸治療的效果及患者妊娠結(jié)局。方法：選擇2020年10月—2021年10月我院收治ICP患者78例作為研究對象，分組應用隨機數(shù)字表法。分為試驗組和對照組各39例，比較兩組臨床療效、患者肝功能、妊娠結(jié)局。結(jié)果：試驗組治療總有效率為94.87%高于對照組的76.92%，差異有統(tǒng)計學意義（P

【關鍵詞】妊娠期內(nèi)膽汁淤積癥；熊去氧膽酸；腺苷蛋氨酸；療效；肝功能；妊娠結(jié)局

Effect of ursodeoxycholic acid on intrahepatic cholestasis of pregnancy （ICP） and pregnancy outcome

LI Pingli

Zigong City Da’an District Maternal and Child Health Care Hospital， Zigong， Sichuan 643000， China

【Abstract】Objective：To explore the effect of ursodeoxycholic acid on intrahepatic cholestasis of pregnancy （ICP） and its pregnancy outcome.Methods：78 ICP patients treated in our hospital from October 2020 to October 2021 were selected as the research object，and randomized digital table was used in groups.They were divided into trial group and control group，with 39 cases in each group.The clinical efficacy， patient liver function and pregnancy outcome of the two groups were compared.Results：The total effective rate of the trial group was 94.87%， which was higher than 76.92% of the control group（P

【Key Words】Intrahepatic cholestasis of pregnancy； Ursodeoxycholic acid； Adenosylmethionine； Efficacy； Liver function； Pregnancy outcome

“妊娠期肝內(nèi)膽汁淤積癥（ICP）”是妊娠中期、晚期特有并發(fā)癥，病理特征是膽汁酸升高、皮膚瘙癢，對胎兒有較大危害，是引起圍生兒患病、死亡風險升高[1]。（剩余4017字）