抑郁癥與肌少癥相關性的研究進展

［摘要］抑郁癥和肌少癥是老年人中常見的兩種疾病，抑郁癥患者因情緒低落、久坐少動等原因可引發(fā)肌少癥，肌少癥因肌肉質量及功能下降，患者缺乏與社會接觸及溝通，患抑郁癥風險增加。運動缺乏、營養(yǎng)不良、氧化應激及炎癥反應等可能是兩者的共同發(fā)病機制。本文就抑郁癥與肌少癥的發(fā)病機制和治療的進展作一綜述。

［關鍵詞］抑郁癥；肌少癥；發(fā)病機制

doi：103969/jissn1674-7593202401016

Research Progress on Correlation between Depression and Sarcopenia

Hu Jianping，Zhao Yuxing，Gao Yuan**

Department of Geriatrics，the First Affiliated Hospital of Chongqing Medical University，Chongqing400016

**Corresponding author：Gao Yuan，email：516504186@qqcom

［Abstract］Depression and sarcopenia represent prevalent conditions among the elderly.The interplay between these two ailments is noteworthy，as depression can contribute to sarcopenia through factors such as diminished mood，sedentary lifestyles，and reduced physical activity.Conversely，sarcopenia is linked to decreased muscle mass and function，limited social interactions，and an elevated risk of depression.Recent research has unveiled a correlation between these conditions，highlighting shared pathogenic elements including exercise deficiency，malnutrition，oxidative stress，and inflammation.This article provides a comprehensive review of advancements in understanding the pathogenesis and treatment modalities for both depression and sarcopenia.By examining the intricate connections between these conditions，it offers valuable insights into potential shared therapeutic interventions and sheds light on holistic approaches to address the complex interplay of depression and sarcopenia in the elderly.

［Key words］Depression；Sarcopenia；Pathogenesis

我國人口老齡化日益嚴重，老年抑郁癥及肌少癥也得到越來越多的關注。（剩余12106字）