免疫治療在前列腺癌中應用的現(xiàn)狀及展望

Immunotherapy for prostate cancer：current status and future perspectives

FANG Bangwei，ZHU Yao

（Department of Urology，F(xiàn)udan University Shanghai Cancer Center，Department of Oncology，Shanghai Medical College，F(xiàn)udan University，Shanghai 200032，China）

ABSTRACT：As an emerging cancer treatment modality，immunotherapy has shown promising efficacy in a variety of solid tumors，but it has failed to achieve a breakthrough in the treatment of prostate cancer.This review aims to provide an overview of the current applications of immunotherapy for prostate cancer，including immune，checkpoint inhibitors， cancer

vaccines and chimeric antigen receptor T，cell （CAR，T），briefly describe the mechanisms of various immunotherapy modalities，summarize the results of clinical trials，and discuss the challenges and prospects.

KEY WORDS：prostate cancer；immunotherapy；tumor immune microenvironment;immune，checkpoint inhibitors;cancer vaccines；CAR，T

摘要：免疫治療作為一種新興的癌癥治療方式，目前已經(jīng)在多種實體腫瘤的治療中表現(xiàn)出了良好的療效，但在前列腺癌中該治療方式未得到突破。（剩余18977字）