基于GSS算法的HRD評(píng)分與高危前列腺癌和轉(zhuǎn)移性激素敏感性前列腺癌患者臨床病理特征、基因組突變和預(yù)后的關(guān)系

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The relationship between HRD score based on GSS algorithm and clinicopathological characteristics，genomic mutations and prognosis in patients with high，risk and metastatic hormone，sensitive prostate cancer

CHEN Zhiqiang，GAO Yu，DU Songliang，NIU Shaoxi，LI Zhuoran，JIA Yuqi，DONG Yujie，WANG Baojun

（Department of Urology，The Third Medical Centre，Chinese PLA General Hospital，Beijing 100039，China）

ABSTRACT：ObjectiveTo statistically analyze the relationship between homologous recombination repair deficiency （HRD） score and

clinicopathological characteristics，genomic mutations in patients with high，risk and metastatic hormone，sensitive prostate cancer （mHSPC） and the prognostic predictive value in mHSPC.MethodsA total of 127 patients diagnosed with high，risk prostate cancer and mHSPC，treated at the Department of Urology of Chinese PLA General Hospital during Dec.2021 and Nov.2023 were enrolled.Homologous recombination repair （HRR） gene sequencing was performed，and the genomic scar score （GSS） algorithm were conducted to calculate the HRD score.The relationship between HRD scores and clinicopathological features，genomic alterations，and prognosis were analyzed.ResultsThe median HRD score was 16（0.8，5.2），30（236%） patients HRD scores ≥10，and 11（87%） patients HRD scores ≥20.Clinicopathological features，including ISUP classification ≥4 （P=0.044） and metastatic status （P=0.008） were associated with high HRD score.Patients with mutations in the BRCA，TP53 and MYC systems had significantly higher HRD score than those with wild，type genes （P<005）.In mHSPC，the risk of biochemical recurrence was 12.836 times higher in patients with HRD score ≥20 than in those with <20 [OR：12.836 （1.332-124.623），P=0.028].ConclusionBaseline HRD score was lower in patients with high，risk prostate cancer and mHSPC.Patients with high HRD score may have higher histological grading （ISUP≥4） and later clinical stage.Further investigation is needed to determine the threshold of HRD scores as biochemical markers suggestive of a poor prognosis.

KEY WORDS：homologous recombination repair;homologous recombination repair deficiency;genomic scar score;high，risk prostate cancer;metastatic hormone，sensitive prostate cancer

摘要：目的分析同源重組修復(fù)缺陷（HRD）評(píng)分與高危

和轉(zhuǎn)移性激素敏感性前列腺癌（mHSPC）患者臨床病理特征、基因組突變的關(guān)系

及對(duì)mHSPC患者預(yù)后的預(yù)測(cè)價(jià)值。（剩余9555字）