高分組前列腺癌組織中PCDH9表達(dá)缺失且與p53、Rb、STAT3的表達(dá)相關(guān)

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The expression of PCDH9 was absent in prostate cancer tissues in the high，score group and was associated with the expressions of p53，Rb and STAT3

WANG Hao1，PENG Lijuan2，XIA Zhongyou1，XU Yulai1，SUN Jing1，ZHANG Xuqian2，LONG Qiongxian2，WU Ji1

（1.Department of Urology，2. Department of Pathology，Nanchong Central Hospital，Second Clinical School of North Sichuan Medical College，Nanchong 637000，China）

ABSTRACT：ObjectiveTo explore the expression of PCDH9 loss in regulating cell cycle and promoting tumor progression. MethodsThe clinical records of 127 cases of prostate cancer treated during 2018 and 2023 were collected，including 87 paraffin tissue samples from the G4-5 group and 40 from the G1-3 group. The expressions of PCDH9，p53，Rb and STAT3 were detected with immunohistochemical staining，and the relationship between their expressions and clinicopathological characteristics was analyzed.ResultsThe expression deletion rate of PCDH9 in prostate cancer tissues in G4-5 group （448% vs.7.5%） was significantly higher than that in G1-3 group （P<0.001）. The positive expression rates of p53 and STAT3 were 34.5% and 89.7%，respectively，and the expression loss rate of Rb was 27.6% in G4-5 group.

The expression loss rates of PCDH9 and Rb were associated with neuroendocrine，like histological morphology，nerve invasion and vascular invasion （P＜0.05）. In G4-5 group of prostate cancer，PCDH9 expression was positively correlated with the expressions of p53 （r=0345，P<0.05），Rb （r=0.503，P<0.05） and STAT3 （r=0.224，P＜0.05）.ConclusionPCDH9 is prone to loss of expression in high，group prostate cancer tissues，especially in cases with neuroendocrine，like histological morphology，which may regulate the cell cycle through the STAT3 signaling pathway，thereby promoting tumor progression.

KEY WORDS：prostate cancer;neuroendocrine；PCDH9；p53；Rb；STAT3；molecular biology；cell cycle；tumor progression

摘要：目的探討前列腺癌中原鈣黏蛋白9（PCDH9）的表達(dá)缺失在調(diào)控細(xì)胞周期、促進(jìn)腫瘤進(jìn)展中的作用。（剩余9873字）