營(yíng)養(yǎng)調(diào)控腸道免疫細(xì)胞活化機(jī)制研究進(jìn)展
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摘 要:腸道微環(huán)境是由腸道細(xì)胞、微生物及其代謝產(chǎn)物組成的微觀內(nèi)環(huán)境,對(duì)腸黏膜免疫系統(tǒng)的結(jié)構(gòu)與功能的塑造至關(guān)重要。本文系統(tǒng)地綜述了腸道微環(huán)境營(yíng)養(yǎng)代謝影響腸黏膜免疫細(xì)胞命運(yùn)的作用機(jī)制,以期更好地理解腸道微環(huán)境與腸道免疫,為腸道健康和相關(guān)疾病的治療提供參考。
關(guān)鍵詞:腸道微環(huán)境;免疫細(xì)胞;腸道微生物;營(yíng)養(yǎng)代謝
中圖分類號(hào):S815
文獻(xiàn)標(biāo)志碼:A
文章編號(hào):0366-6964(2024)07-2846-13
收稿日期:2023-09-28
基金項(xiàng)目:國(guó)家重點(diǎn)研發(fā)計(jì)劃(2022YFD1300403);國(guó)家自然科學(xué)基金(U22A20510);國(guó)家自然科學(xué)基金青年基金項(xiàng)目(32102571);湖南省自然科學(xué)基金優(yōu)秀青年項(xiàng)目(2022JJ20027);中國(guó)農(nóng)業(yè)科研系統(tǒng)專項(xiàng)基金(CARS-35);云南省重大科技專項(xiàng)(202102AE090046)
作者簡(jiǎn)介:宋云方(2000-),女,四川南充人,碩士生,主要從事仔豬腸道發(fā)育與免疫研究,E-mail:[email protected]
*通信作者:王 婧,主要從事仔豬腸道發(fā)育、母仔營(yíng)養(yǎng)傳遞及調(diào)控研究,E-mail:[email protected]
Research Progress on the Mechanism of Nutrition Regulating Intestinal Immune
Cell Activation
SONGYunfang1,2,CHENGHao1,2,F(xiàn)ENGLuya1,2,BAIPing4,DENGYuankun1,2,
XIAYaoyao3,TANBi’e1,2,WANGJing1,2*
(1.Animal Nutrition Genomics and Germplasm Innovation Center,College of Animal
Science and Technology,Hunan Agricultural University,Changsha410128,China;
2.Yuelushan Laboratory,Changsha410128,China; 3.College of Animal Science
and Technology,Southwest University,Chongqing400715,China; 4.Yunnan
Southwest Agriculture and Animal Husbandry Group Co.,Ltd,Kunming650224,China)
Abstract:The intestinal microenvironment is amicroscopic internal environment composed of intestinal cells,microorganisms and their metabolites,which is crucial to the structure and function shaping of intestinal mucosal immune system.This paper systematically reviews the mechanisms of intestinal microenvironment nutrition metabolism affecting the fate of intestinal mucosal immune cells,in order to better understanding the intestinal microenvironment and intestinal immunity,and providing references for the treatment of intestinal health and related diseases.
Key words:intestinal microenvironment; immune cells; gut microbes; nutrient metabolism
*Corresponding author:WANG Jing,E-mail:[email protected]
健康的腸道對(duì)于多種生理過(guò)程至關(guān)重要,它在免疫防御和營(yíng)養(yǎng)的消化、吸收方面均發(fā)揮著顯著作用[1-2]。(剩余26422字)