甲基轉(zhuǎn)移酶樣蛋白3與前列腺癌患者預(yù)后的相關(guān)性

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Association between methyltransferase-like 3 and prognosis in patients with prostate cancer

ABSTRACT：Objective To explore the association between methyltransferase-like 3 （METTL3） and prostate cancer （PCa） prognosis，so as to establish a novel prognostic prediction model for PCa.Methods Public datasets and PCa tissue microarray were used to evaluate the gene and protein expressions of METTL3，the association between METTL3 and Gleason score （GS），and the ability of METTL3 to predict poor outcomes of PCa.A nomogram was constructed to quantitatively evaluate the prognosis of PCa.Results The gene and protein expressions of METTL3 were significantly upregulated in PCa tissues compared to normal tissues （P<0.05）.Moreover，the expressions of METTL3 were significantly higher in high-risk PCa tissues （GS>7） compared to low-moderate risk PCa tissues （GS≤7） （P<0.05）.Patients with elevated expressions of METTL3 exhibited poorer short-term and long-term progression-free and overall survival outcomes when compared to those with lower expressions of METTL3 （P<0.05）.In addition，a risk model composed of 7 target genes regulated by METTL3 N6-methyladenine （m6A） modification was established.The 7 target genes were closely associated with the cell cycle process.The protein expression of METTL3 exhibited a significant positive correlation with the protein expression of cell cycle protein B1 （CCNB1） （r=0.30，P=0.002 5）.Conclusion METTL3 exhibits the potential as a prognostic predictor for PCa，which may affect PCa prognosis through the regulation of the expressions of target genes closely associated with the cell cycle process via m6A modification.

KEY WORDS：prostate cancer; prognostic predictor; progression-free interval; progression free-survival; methyltransferase-like 3; N6-methyladenine; nomogram model

摘要：

目的 探討甲基轉(zhuǎn)移酶樣蛋白3（METTL3）與前列腺癌（PCa）患者預(yù)后的相關(guān)性，以期建立新的預(yù)測PCa患者預(yù)后的方法。（剩余12584字）