高齡（≥40歲）男性的多精受精指標(biāo)可能與年輕男性并無顯著差異：一項(xiàng)傾向性評(píng)分匹配研究

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No difference in polyspermia index between older men（≥40 years） and younger men：a propensity score matching study

ABSTRACT：Objective To investigate the effects of advanced male age on the incidence of polyspermy fertilization.Methods The study involved data of 4210 in vitro fertilization （IVF） cycles treated in our center during Jan.2016 and Sep.2022，including 4053 patients younger than 40 years and 157 patients above 40 years.After propensity score matching，152 patients in the advance group and 421 in the young group were recruited.The baseline data and the difference in polyspermy fertilization rate were compared between the two groups.Results After propensity score matching，there were no significant differences between the two groups in terms of female age，infertility type，infertility years，infertility factors，female body mass index （BMI），male BMI，semen volume，semen pH value，sperm concentration，sperm motility，progressive motility rate，percentage of normal sperm morphology，number of fertilized eggs and number of MⅡ eggs （P＞0.05）.Among the 573 fresh IVF cycles，the rate of 3 PN cycles was 35.5%，and the incidence of polyspermy fertilization was 6.5%.There were no significant differences in the number of polyspermy fertilized eggs，transferable embryos，high-quality embryos，and blastocysts between the two groups.Conclusion Advanced male age has no significant effect on the incidence of polyspermy fertilization.

KEY WORDS：in vitro fertilization；multiple pronuclei；propensity score matching；transferable embryos；advanced male age

摘要：目的 探討男性高齡因素對(duì)多精受精發(fā)生率的影響。（剩余8572字）