機(jī)械通氣病人多重耐藥菌感染危險(xiǎn)因素的Meta分析

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Risk factors of multidrug-resistant organism infection in patients with mechanical ventilation：a Meta-analysis

WEI Jingjing，WU Haiqing，YANG Tao，YU Haohui，TAO Shengru

School of Nursing，Jinan University，Guangdong 510632 China

Corresponding Author  TAO Shengru，E-mail：[email protected]

AbstractObjective：To systematicly evaluate the risk factors of multidrug-resistant organism infection in patients with mechanical ventilation.Methods：Related literatures on risk factors of multidrug-resistant organism infection in patients with mechanical ventilation were searched from PubMed，EMbase，Web of Science，the Cochrane library，CBM，CNKI，WanFang Database，VIP.Two researchers independently carried out literature retrieval，screening，quality evaluation and data extraction，and RevMan 5.4.1 software was used for data analysis.Results：A Total of 15 articles were included，involving 5 290 patients with mechanical ventilation，including 1 463 patients with multidrug-resistant organism infection.Meta-analysis results showed that smoking，combined chronic obstructive pulmonary disease，serum albumin<30 g/L，tracheotomy，multiple endotracheal intubations，mechanical ventilation time ≥ 7 days，antibacterial drug combination，using penicillium carbon alkene antimicrobial and β-lactamase inhibitor containing antimicrobial，antibacterial drug use time ≥7 days，glucocorticoid treatment>3 days were risk factors for multidrug-resistant organism infection in inpatients with mechanical ventilation.Conclusion：Current evidence shows that smoking，combined chronic obstructive pulmonary disease，serum albumin<30 g/L，tracheotomy，multiple endotracheal intubations，mechanical ventilation time ≥ 7 days，antibacterial drug combination，using penicillium carbon alkene antimicrobial and β-lactamase inhibitor containing antimicrobial，antibacterial drug use time ≥7 days，glucocorticoid treatment>3 days are risk factors for multidrug-resistant organism infection in in patients with mechanical ventilation.Medical staff should carry out precise intervention against risk factors to reduce the risk of multidrug-resistant organism infection in patients with mechanical ventilation.

Keywordsmechanical ventilation;multidrug-resistance organism;risk factors;Meta-analysis;evidence-based nursing

摘要目的：對(duì)機(jī)械通氣病人多重耐藥菌感染的危險(xiǎn)因素進(jìn)行系統(tǒng)評(píng)價(jià)。（剩余12474字）