秀麗隱桿線蟲在中藥抗衰老研究中的應(yīng)用

打開文本圖片集

〔摘要〕 中藥作為一種毒副作用少的天然物質(zhì)，在抗衰老研究領(lǐng)域有巨大的潛力。本文就近年來以秀麗隱桿線蟲為動物模型，探索中藥通過對多種信號通路及衰老相關(guān)基因的調(diào)控發(fā)揮抗衰老作用的研究進(jìn)行綜述，為深入探索中藥延緩衰老的生物活性和分子機制提供理論依據(jù)和試驗參考。

〔關(guān)鍵詞〕 中藥;衰老;抗衰老;秀麗隱桿線蟲;衰老動物模型;信號通路;作用機制

〔中圖分類號〕R285.5       〔文獻(xiàn)標(biāo)志碼〕A        〔文章編號〕doi：10.3969/j.issn.1674-070X.2022.09.029

Application of Caenorhabditis elegans against aging in traditional Chinese medicine

LIU Jin， ZHOU Lei， BU Lanlan， CHENG Shaowu ZHENG Xilong

（Hunan University of Chinese Medicine， Changsha， Hunan 410208， China）

〔Abstract〕 Traditional Chinese medicine， as the natural substance with low toxic and side effects， has great potential in anti-aging research. This paper reviews the recent studies on the anti-aging effects of traditional Chinese medicine through the regulation of various signaling pathways and aging-related genes using Caenorhabditis elegans， so as to provide theoretical basis and experimental reference for further exploration of the biological activities and molecular mechanisms of traditional Chinese medicine in delaying aging.

〔Keywords〕 traditional Chinese medicine; aging; anti-aging; Caenorhabditis elegans; aging animal model; signaling pathway; mechanism of action

衰老是一個復(fù)雜的、多因素相互作用所決定的必然的生理過程[1]，并且伴隨多種疾病的發(fā)生，如代謝性疾病[2]、心血管疾病[3]、呼吸系統(tǒng)疾病[4]、自身免疫性疾病[5]和神經(jīng)系統(tǒng)疾病[6]等。（剩余17317字）