線粒體途徑凋亡及中醫(yī)藥應用在帕金森病中的研究進展

［摘要］帕金森?。≒D）是一種神經系統退行性疾病，病程長、易復發(fā)?？蓪е录×Α⒆藙?、步態(tài)及精神等異常，繼而引發(fā)殘疾。線粒體途徑的細胞凋亡是導致PD發(fā)病的重要的可能因素，本文對線粒體途徑凋亡與PD的關系、中醫(yī)藥對PD病機的探討及其治療作用作一綜述，探索中醫(yī)藥對于PD的有效治療手段。

［關鍵詞］帕金森病；線粒體凋亡；中醫(yī)藥應用

doi：10.3969/j.issn.1674-7593.2023.04.021

ResearchProgressonMitochondrialPathwayApoptosisandApplicationsofTraditionalChineseMedicineinParkinson'sDisease

WangLei1，LiuDeshui2，ZhangYingbo2，ZhangXiaojie1，2，3**

1BasicMedicalCollege，HeilongjiangUniversityofChineseMedicine，Harbin150006;2DepartmentofPathology，QiqiharMedicalUniversity，Qiqihar161003;3HeilongjiangNursingCollege，Harbin150086

**Correspondingauthor：ZhangXiaojie，email：[email protected]

［Abstract］Parkinson'sdisease（PD）isaprevalentneurodegenerativedisordercharacterizedbyachronicandrelapsingcourse.PDgivesrisetodiversefunctionalimpairments，encompassingabnormalitiesinmusclestrength，posture，gait，andmentalwell-being，oftenleadingtodisability.TheinvolvementofmitochondrialapoptosisholdssignificantrelevanceinthepathogenesisofPD.ThiscomprehensivearticleextensivelyexaminestheintricatemechanismsunderlyingPD-associatedmitochondrialpathwayapoptosis，whiledelvingintothepotentialtherapeuticstrategiesofferedbytraditionalChinesemedicine（TCM）forthemanagementofPD.ByexploringtheinterplaybetweenPDpathogenesisandTCM，thisstudyaimstoshedlightoneffectivetreatmentmodalitiesandbroadentheunderstandingofTCM'stherapeuticpotentialinPD.

［Keywords］Parkinson'sdisease;Mitochondrialapoptosis;TraditionalChinesemedicineapplication

帕金森?。≒arkinson'sdisease，PD）是以中腦黑質致密部多巴胺能（Dopaminergic，DA）神經元的變性缺失為主要病理改變、以運動癥狀和非運動癥狀為主要表現的全球第二大神經系統退行性疾病，起病隱匿，進展緩慢［1-2］。（剩余7291字）