輸尿管遠(yuǎn)端結(jié)石藥物排石治療研究進(jìn)展

Research progress in the treatment of distal ureteral calculi with drugs

LI Zhouxin1， ZHANG Lei1， CHENG Yue2，3， XIE Guohai3，4

（1.School of Medicine， Ningbo University， Ningbo 315000；2.Ningbo Clinical Medical Research Center of Urinary Diseases， Ningbo 315500；3.Urinary System Disease Innovation Technology and Diagnosis and Treatment Equipment Zhejiang Engineering Center， Ningbo 315500；4.Department of Urology， The First Affiliated Hospital of Ningbo University， Ningbo 315500，China）

ABSTRACT：Renal colic caused by ureteral stone obstruction is the main cause for emergency treatment of patients with urinary tract stones， and drug expulsion therapy plays a vital role in the treatment.This article delves into a variety of drugs， including α1 adrenergic receptor blockers，β adrenergic receptor agonists， calcium channel blockers， prostaglandin synthetase inhibitors， corticosteroids， phosphodiesterase isoenzyme 5 inhibitors， and Chinese herbal medicines， exploring their mechanisms and applications in the treatment of distal ureteral stones.Currently， α1 adrenergic receptor blockers are still preferred for the treatment of distal ureteral stones due to their significant efficacy.It is worth noting that various drugs work through different mechanisms， and combining drugs with different mechanisms is expected to improve the efficiency of stone expulsion.This method may become the mainstream choice for stone expulsion drugs in the future.This article aims to provide new perspectives and ideas for the drug treatment of urinary tract stones.

KEY WORDS：distal ureteral calculi; medical expulsive therapy;α1 adrenergic receptor blocker;β adrenergic receptor agonists; calcium channel blockers; prostaglandin synthetase inhibitors; corticosteroids; phosphodiesterase isoenzyme 5 inhibitors

摘要：輸尿管結(jié)石梗阻引發(fā)的腎絞痛是尿路結(jié)石患者急診就診的主要原因，藥物排石療法在治療中發(fā)揮著重要的作用。（剩余12362字）