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基于SEER數(shù)據(jù)庫分析檢查淋巴結(jié)數(shù)及陽性淋巴結(jié)比率用于前列腺癌患者生存預(yù)后評估的價值

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Survival prognosis evaluation value of examined lymph nodes and positive lymph node ratio in prostate cancer

WANG Jinru1，BU Ke1，AN Hengqing2，TAO Ning1

（1.College of Public Health，Xinjiang Medical University，Urumqi 830017；2.Department of Urology，The First Affiliated Hospital of Xinjiang Medical University，Urumqi 830054，China）

ABSTRACT：Objective To explore the number of examined lymph nodes （ELN） and positive lymph node ratio （LNR） in the prediction of 5-year and 10-year overall survival （OS） and cancer-specific survival （CSS） of prostate cancer （PCa） patients，so as to provide reference for clinical practice.Methods Information of PCa patients screened in the Surveillance，Epidemiology and End Results （SEER） database during 2010-2020 were analyzed. A total of 1842 PCa patients were assigned to the training set （n=1290） and validation set （n=552） in a 7∶3 ratio with R 4.3.0 software. Significant factors in the multivariate Cox proportional risk regression model were adjusted，restricted cubic spline plots （RCS） were plotted，the optimal cut-off values of ELN and LNR were determined，and the 5-year and 10-year OS and CSS were analyzed with restricted mean survival time （RMST）.Results Multivariate Cox analysis showed that there was a 2.9% reduction in the risk of death with an increase of 1-unit ELN and a 3.1% reduction in the risk of cancer-specific death. There was a 481.4% increase in the risk of death with a 1-unit increase in LNR and a 667.5% increase in the risk of cancer-specific death. The risk of overall death and cancer-specific death in ELN and PCa patients showing a non-linear relationship （P＜0.001），while in the LNR and PCa patients showing a linear relationship （P＞0.05）. RMST results showed that the optimal ELN range for evaluating OS was 12-29，the optimal ELN range for assessing CSS was 12-25，LNR>0.152 indicated poor prognosis.Conclusion We have clarified the range of ELN and LNR，which can provide reference for the clinical precision diagnosis and treatment of PCa.

KEY WORDS：prostate cancer；examined lymph nodes；positive lymph node ratio；overall survival；cancer-specific survival

摘要：目的 基于監(jiān)測、流行病學(xué)和最終結(jié)果（SEER）數(shù)據(jù)庫分析檢查淋巴結(jié)數(shù)（ELN）及陽性淋巴結(jié)比率（LNR）預(yù)測前列腺癌（PCa）患者5年、10年總生存期（OS）和腫瘤特異性生存期（CSS）的價值，以期為PCa患者的臨床診療提供參考。（剩余10626字）

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