卵巢癌鉑耐藥及其治療研究進(jìn)展

［摘要］

卵巢癌是惡性程度最高的婦科惡性腫瘤之一。以鉑為基礎(chǔ)的化療是卵巢癌治療的重要組成部分，因此鉑耐藥也是卵巢癌治療中棘手的問題。鉑耐藥是一個復(fù)雜的過程，涉及多種機(jī)制。本文就卵巢癌細(xì)胞鉑耐藥的分子機(jī)制及治療進(jìn)展作一綜述，以期為該病的臨床治療提供借鑒。

［關(guān)鍵詞］ 卵巢腫瘤；鉑；抗腫瘤藥；抗藥性，腫瘤；綜述

［中圖分類號］ R737.31；R915

［文獻(xiàn)標(biāo)志碼］ A

Research advances in platinum resistance and its treatment in ovarian cancer

LIU Yan， HUANG Li

（Department of Gynecology， Laizhou People’s Hospital， Laizhou 261400， China）

; ［ABSTRACT］ Ovarian cancer is one of the most malignant gynecological tumors. Platinum-based chemotherapy is an important part of ovarian cancer treatment， with platinum resistance as a difficult problem in ovarian cancer treatment. Platinum resis-

tance is a complex process involving a variety of mechanisms. This article reviews the molecular mechanisms of platinum resistance in ovarian cancer cells and the advances in treatment， in order to provide a reference for the clinical treatment of this disease.

［KEY WORDS］ Ovarian neoplasms; Platinum; Antineoplastic agents; Drug resistance， neoplasm; Review

卵巢癌是全球范圍內(nèi)發(fā)病率和死亡率較高的疾病［1］，也是惡性程度最高的婦科惡性腫瘤之一，死亡率極高［2］。（剩余15168字）