真實(shí)世界中聯(lián)用丙戊酸鹽對(duì)奧氮平血藥濃度的影響

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[摘要] 目的 了解真實(shí)世界中聯(lián)用丙戊酸鹽對(duì)奧氮平血藥濃度的影響。方法 調(diào)查2018年1月至2020年7月浙江省紹興市第七人民醫(yī)院住院服用奧氮平并有血藥濃度檢測(cè)結(jié)果的患者，采用傾向評(píng)分匹配，對(duì)聯(lián)合使用丙戊酸鹽組（聯(lián)用組）和未聯(lián)用丙戊酸鹽組（對(duì)照組）進(jìn)行1∶1匹配，并對(duì)匹配后的數(shù)據(jù)進(jìn)行分析。結(jié)果 1796例進(jìn)入統(tǒng)計(jì)，428對(duì)患者匹配成功，對(duì)匹配后的數(shù)據(jù)分析，結(jié)果顯示聯(lián)用組的奧氮平血藥濃度中位數(shù)較對(duì)照組低22.83%（P

[關(guān)鍵詞] 丙戊酸鹽;奧氮平;血藥濃度;傾向得分匹配

[中圖分類號(hào)] R749          [文獻(xiàn)標(biāo)識(shí)碼] B          [文章編號(hào)] 1673-9701（2022）06-0099-05

[Abstract] Objective To understand the effect of combined valproic acid on the plasma concentration of olanzapine in the real world. Methods Inpatients who took olanzapine with plasma concentration test results from January 2018 to July 2020 in Shaoxing 7th People′s Hospital in Zhejiang Province were surveyed. The propensity score matching method was used to match the combined valproic acid group （the combined group） and the non-combined valproic acid group （the control group） by 1∶1， and the matched data were analyzed. Results A total of 1796 cases were counted， and 428 pairs of patients were successfully matched. The analysis of the matched data showed that the median plasma concentration of olanzapine in the combination group was 22.83% lower than that in the control group （P

[Key words] Valproic acid; Olanzapine; Plasma concentration; Propensity score matching

奧氮平是第二代抗精神病藥，在精神分裂癥和雙相障礙的治療中曾長(zhǎng)期作為一線治療藥物，僅在近年來(lái)因其對(duì)代謝的影響等原因降為二線推薦藥物[1-4]，而丙戊酸鹽作為一線的心境穩(wěn)定劑，常聯(lián)合抗精神病藥用于治療雙相障礙，其中與奧氮平的聯(lián)合使用也較為常見(jiàn)[2，3，5]。（剩余7356字）