膝痹膏皮膚用藥安全性研究

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【摘 要】目的：對(duì)膝痹膏皮膚用藥的安全性進(jìn)行探討。方法：以兔、豚鼠為模型進(jìn)行動(dòng)物實(shí)驗(yàn)，分別觀察膝痹膏對(duì)家兔完整皮膚組和破損皮膚組的刺激反應(yīng)，并進(jìn)行豚鼠的皮膚過(guò)敏反應(yīng)實(shí)驗(yàn)。結(jié)果：膝痹膏外用對(duì)兔的完整或破損皮膚均無(wú)刺激性。并且外用后未出現(xiàn)紅腫、水腫等過(guò)敏現(xiàn)象。結(jié)論：膝痹膏臨床皮膚用藥安全、無(wú)毒。

【關(guān)鍵詞】膝痹膏；皮膚刺激性實(shí)驗(yàn)；皮膚過(guò)敏性實(shí)驗(yàn)

【中圖分類號(hào)】R285.5 【文獻(xiàn)標(biāo)志碼】 A 【文章編號(hào)】1007-8517（2024）06-0025-03

DOI：10.3969/j.issn.1007-8517.2024.06.zgmzmjyyzz202406006

Safety Study of Shin Medication of Knee and ArthraLgia HerbaL Paste

GUO Tongtong1，2 LI Hongfei1 GUOXiying1 LIU Junchang2*

1.Children’s Hospital of Xinjiang Uygur Autonomous Region/Xinjiang Hospital of Beijing Children’s Hospital，Urumqi 830000，China;2.Xinjiang Medical University，Urumqi 830011，China

Abstract：Objective To discussthe safety of dermatologic using of Knee and ArthraLgia HerbaL Paste.Method As a model for animal experiment， rabbits， guinea pigs were observed Knee and ArthraLgia HerbaL Paste to the stimulation of rabbit skin and damaged skin group complete response， and guinea pig skin allergic reaction experiments. Results External application of Knee and ArthraLgia HerbaL Paste has no irritation on intact or damaged skin of rabbits.And after external use did not appear redness，oedema and other allergic phenomena.Conclusion Knee and ArthraLgia HerbaL Paste is safe and nontoxic in clinical medication.

Key words：Knee and ArthraLgia HerbaL Paste; irritation experiment; hypersensitivity experiment

膝痹膏處方源自《千金翼方·卷十六·諸膏第三》蒼梧道士陳元膏，并且在《肘后救卒方》《千金要方》等書(shū)中均有記載，其中記載“患膝冷痛，摩之五日，亦愈”。（剩余2753字）