膿毒癥相關(guān)性急性腎損傷的發(fā)病機(jī)制

摘要：膿毒癥是由嚴(yán)重感染引起的炎癥反應(yīng)，可導(dǎo)致多器官損傷，包括急性腎損傷（AKI）。本文主要對膿毒癥相關(guān)性急性腎損傷（S-AKI）的發(fā)病機(jī)制、危險(xiǎn)性因素、診斷與治療情況等進(jìn)行綜述，以期為臨床上更好地診治膿毒癥，改善患者的預(yù)后提供指導(dǎo)。

關(guān)鍵詞：膿毒癥；急性腎損傷；炎癥反應(yīng)；發(fā)病機(jī)制

中圖分類號：R631                                    文獻(xiàn)標(biāo)識碼：A                                DOI：10.3969/j.issn.1006-1959.2024.05.033

文章編號：1006-1959（2024）05-0174-05

Pathogenesis of Sepsis-associated Acute Kidney Injury

HE Jiao-long1，NIE Fang-fei1，HU Long1，XU Yun-ling2

（1.Intensive Care Unit，the First Affiliated Hospital of Jishou University/People's Hospital of Xiangxi Tujia

and Miao Autonomous Prefecture，Jishou 416000，Hunan，China;

2.Institute of Basic Experiment，Tongde Hospital of Zhejiang Province/Zhejiang Province Institute of Traditional Chinese Medicine，Hangzhou 310007，Zhejiang，China）

Abstract：Sepsis is an inflammatory response caused by severe infection， which can lead to multiple organ damage， including acute kidney injury （ AKI ）. This article mainly reviews the pathogenesis， risk factors， diagnosis and treatment of sepsis-associated acute kidney injury （ S-AKI ）， in order to provide guidance for better clinical diagnosis and treatment of sepsis and improve the prognosis of patients.

Key words：Sepsis;Acute kidney injury;Inflammatory reaction;Pathogenesis

膿毒癥（sepsis）是指病菌入侵血液循環(huán)后機(jī)體內(nèi)免疫反應(yīng)紊亂，引起全身炎癥反應(yīng)的綜合征，以發(fā)熱、心慌、氣促和精神狀態(tài)變化為主要癥狀，嚴(yán)重的膿毒血癥常出現(xiàn)循環(huán)障礙和（或）器官功能障礙[1]。（剩余8099字）