性激素參與痛風(fēng)發(fā)病機制的研究進展

【摘要】 痛風(fēng)在男性和絕經(jīng)后女性中的發(fā)病率升高提示痛風(fēng)與性別密切相關(guān)，且受體內(nèi)性激素的影響。然而，性激素是如何參與痛風(fēng)發(fā)病的，二者真正的關(guān)系如何目前并不十分清楚。該文結(jié)合近年來痛風(fēng)研究的相關(guān)進展，對性激素在痛風(fēng)發(fā)病中的作用機制進行綜述。

【關(guān)鍵詞】 痛風(fēng)；性激素；雌激素；雄激素；發(fā)病機制

Advances in the study of the role of sex hormones in the pathogenesis of gout Tian Mengxin， Zhao Yi. Department of Rheumatology and Immunology， Xuanwu Hospital， Capital Medical University， Beijing 100053， China

Corresponding author， Zhao Yi， E-mail： [email protected]

【Abstract】 The increased incidence of gout in men and postmenopausal women suggests that gout is closely associated with sex and affected by sex hormones. However， how sex hormones are involved in the onset of gout and the exact relationship between these two are poorly understood. In this article， recent advances in the study of gout were summarized， and the mechanism underlying the role of sex hormones in the pathogenesis of gout was reviewed.

【Key words】 Gout； Sex hormone； Estrogen； Androgen； Pathogenesis

流行病學(xué)研究顯示，痛風(fēng)的總體發(fā)病率和患病率呈增長趨勢：2017年全球年齡標準化患病率和發(fā)病率分別相比1990年增加了7.2%，其中我國1990—2019年間痛風(fēng)患病人數(shù)增長了175.6%，發(fā)病人數(shù)增加了157.31%［1-2］。（剩余8312字）