硫化氫與結(jié)直腸癌

摘 要 機體內(nèi)的硫化氫是一種微量氣體信號分子，在腸道中由腸上皮細胞和腸道菌群代謝產(chǎn)生。越來越多的研究表明，結(jié)直腸癌患者伴有腸道菌群失衡和體內(nèi)硫化氫水平增高現(xiàn)象。本文概要介紹機體內(nèi)硫化氫的產(chǎn)生途徑及其生理和病理作用，并討論了未來呼出氣中硫化氫水平用于結(jié)直腸癌篩查與預(yù)警的可能性。

關(guān)鍵詞 結(jié)直腸癌 硫化氫 腸道菌群 胱硫醚β-合酶

中圖分類號：R333.3； R735.3 文獻標(biāo)志碼：A 文章編號：1006-1533（2024）19-0012-04

引用本文 陳堅， 張會祿， 潘亦達， 等. 硫化氫與結(jié)直腸癌[J]. 上海醫(yī)藥， 2024， 45（19）： 12-15； 21.

Hydrogen sulfide and colorectal cancer

CHEN Jian， ZHANG Huilu， PAN Yida， LIU Jie

（Department of Gastroenterology， Huashan Hospital， Fudan University， Shanghai 200040， China）

ABSTRACT Hydrogen sulfide is a trace gas signaling molecule that is metabolized in the gut by intestinal epithelial cells or intestinal microbiota using cysteine as its substrate. More and more studies have confirmed that patients with colorectal cancer are accompanied by gut flora disturbance and an increase in the level of hydrogen sulfide synthesis in the body. The pathway of hydrogen sulfide production and its physiological and pathological effects in colorectal cancer were reviewed in the present paper. The value of exhaled hydrogen sulfide in screening and early prediction of colorectal cancer as a novel target was also discussed.

KEY WORDS colorectal cancer； hydrogen sulfide； gut flora； cystathionine β-synthase

硫化氫是一種無色、易燃的酸性氣體，低濃度時有特征性的臭雞蛋氣味。（剩余11398字）