水通道蛋白4抗體陰性視神經(jīng)炎臨床與磁共振影像研究
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摘 要 目的:通過(guò)水通道蛋白4(AQP4)抗體陰性視神經(jīng)炎臨床與磁共振影像研究,探討影響視神經(jīng)的獨(dú)立危險(xiǎn)因素。方法:回顧性分析我院50例AQP4抗體陰性視神經(jīng)炎患者的臨床資料。結(jié)果:在基線水平上及治療后的隨訪終點(diǎn)發(fā)現(xiàn)50例患者中分別有85、26只眼睛的最佳矯正視力低于0.1;急性期視神經(jīng)炎患者核磁共振成像(MRI)有36例出現(xiàn)多節(jié)段受累;多元逐步回歸分析發(fā)現(xiàn),基線視力水平、視神經(jīng)受累節(jié)段數(shù)量是影響視神經(jīng)的獨(dú)立危險(xiǎn)因素(P
關(guān)鍵詞 視神經(jīng)炎 水通道蛋白4抗體 臨床資料 磁共振影像
中圖分類號(hào):R744.61 文獻(xiàn)標(biāo)志碼:B 文章編號(hào):1006-1533(2024)17-0073-04
引用本文 溫延斌, 郭年波, 欒麗娟, 等. 水通道蛋白4抗體陰性視神經(jīng)炎臨床與磁共振影像研究[J]. 上海醫(yī)藥, 2024, 45(17): 73-76.
基金項(xiàng)目:江西省衛(wèi)健委科技計(jì)劃項(xiàng)目(202140662)
Clinical and magnetic resonance imaging study of aquaporin 4 antibody negative optic neuritis
WEN Yanbin, GUO Nianbo, LUAN Lijuan, LIU Pinglan, LIU Qisheng
(Ganzhou Qimingxing Eye Hospital, Ganzhou 341000, China)
ABSTRACT Objective: To discuss the independent risk factors affecting the optic nerve by clinical and magnetic resonance imaging study of aquaporin 4 (AQP4) antibody negative optic neuritis. Methods: The clinical data from 50 patients with AQP4 antibody negative optic neuritis in our hospital were retrospectively analyzed. Results: There were 85 and 26 eyes in 50 patients with optimal corrected visual acuity less than 0.1 at baseline and at the end of follow-up after treatment. Multiple segmental involvement was observed in 36 patients with acute optic neuritis by MRI. Multiple stepwise regression analysis showed that baseline visual acuity level and the number of involved optic nerve segments were the independent risk factors affecting the final optic nerve (P
KEY WORDS optic neuritis; aquaporin 4 antibody; clinical data; magnetic resonance imaging
視神經(jīng)炎是臨床上眼科常見(jiàn)的一種疾病,泛指包括炎癥、外傷、退變以及脫髓鞘疾病等能夠阻礙視神經(jīng)的信號(hào)傳導(dǎo),引起視功能改變的一類視神經(jīng)病變,是中、青年人群重要的致盲原因之一[1-2]。(剩余5547字)