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多囊卵巢綜合征動物模型研究進展

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[摘要]

多囊卵巢綜合征(PCOS)是一種以稀發(fā)排卵或無排卵、高雄激素血癥及卵巢多囊樣改變?yōu)橹饕卣鞯拇x性疾病。目前尚無動物模型能夠全面地覆蓋PCOS所有臨床表現(xiàn)。本文綜述了常見的PCOS動物模型,并總結(jié)了其生殖與代謝特征。

[關鍵詞] 多囊卵巢綜合征;疾病模型,動物;綜述

[中圖分類號] R711.75

[文獻標志碼] A

[文章編號] 2096-5532(2024)05-0787-04

doi:10.11712/jms.2096-5532.2024.60.171

[網(wǎng)絡出版] https://link.cnki.net/urlid/37.1517.R.20241127.0854.001;2024-11-27 15:01:25

Research advancesin animal models of polycystic ovary syndrome

LIU Fang, XU Lin

(Department of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China)

[Abstract] Polycystic ovary syndrome (PCOS) is a metabolic disease characterized by oligo-ovulation or anovulation, hyperandrogenism, and polycystic ovary changes. At present, no animal model can fully cover all clinical manifestations of PCOS. This article reviews the common animal models of PCOS and summarizes its reproductive and metabolic characteristics.

[Key words] polycystic ovary syndrome; disease models, animal; review

多囊卵巢綜合征(PCOS)是導致育齡期女性排卵障礙不孕的主要原因之一,其患病率大約為20%[1-2]。(剩余13355字)

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