清肺解毒丸的提取工藝研究

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【摘 要】 目的：通過正交試驗優(yōu)選清肺解毒丸的提取工藝。方法：建立梔子苷的HPLC測定方法，通過正交實驗確定最佳提取工藝。結(jié)果：清肺解毒丸的提取工藝為皂角刺、梔子等十一味加水煎煮3次，每次加10倍量水，煎煮1.5h。結(jié)論：優(yōu)選出的清肺解毒丸提取工藝穩(wěn)定、合理可行，為清肺解毒丸的合理開發(fā)提供參考。

【關(guān)鍵詞】 提取工藝;梔子苷;正交設(shè)計;清肺解毒丸

【中圖分類號】R284.2 【文獻標(biāo)志碼】 A【文章編號】1007-8517（2022）13-0039-04

Study on the Extraction Process of Qingfei Jiedu Pills

KANG Shaojian1，2 WANG Piao1，3 ZHU Zhikun1，3 GUO Yuanyuan1，3 CHEN Lingyun1，3*

1.Yunnan University of Traditional Chinese Medicine， Kunming 650500，China;2.Yunnan Food and Drug Inspection Center，Kunming 650011，China;3. Yunnan Provincial Key Laboratory of External Drug Delivery System and Preparation Technology Research.Kunming 650011，China

Abstract：Objective To optimize the extraction process of Qingfei Jiedu Pills.Methods A HPLC method was established to determination the content of geniposide， and the optimal extraction process was determined by orthogonal test.Results The extraction process was determined by orthogonal test. Results the extraction process of Qingfei Jiedu pill was as follows： 11 kinds of flavors， such as Gleditsia sinensis， garden seed， etc， were decocted with water for 3 times， 10 times of water was added each time， and decocted for 1.5 hours.Conclusion The optimized extraction process of Qingfei Jiedu Pills is stable， reasonable and feasible， and provides a reference for the rational development of Qingfei Jiedu Pills.

Key words：Preparation Process; Geniposide; Orthogonal Design;Qingfei Jiedu Pills

清肺解毒丸由金銀花、梔子、皂角刺等十七味中藥組成，該方具有清熱解毒、燥濕散結(jié)之功效。（剩余4264字）