奶酪攝入量與骨關(guān)節(jié)炎關(guān)聯(lián)性的雙樣本孟德?tīng)栄芯?/h1>

打開(kāi)文本圖片集

Associations of cheese intake with osteoarthritis：a Mendelian randomization study

Abstract  Objective：Using Mendelian randomization method，explore the causal relationship between cheese intake and the risk of osteoarthritis.Methods：Data from gene-wide association studies were used for analysis.The exposure factor was cheese intake，and the outcome variable was osteoarthritis.Mendelian randomization（MR） analysis was performed by IVW method，MR-Egger method and weighted median，and pleiotropy test，heterogeneity test and sensitivity analysis were performed.Results：The results of IVW and weighted median showed that cheese intake was a protective factor for osteoarthritis，and there was a negative causal association between them（P<0.05）.The MR-Egger regression showed no statistically significant association between cheese intake and osteoarthritis（P=0.335）.The results were tested for no heterogeneity or pleiotropy，and sensitivity analyses did not identify SNPs that significantly changed the overall causal relationship.Conclusion：Cheese intake is causally related to osteoarthritis.

Keywords  cheese intake； osteoarthritis； Mendelian randomization

摘要  目的：采用孟德?tīng)栯S機(jī)化的方法，探討奶酪攝入量與骨關(guān)節(jié)炎發(fā)生風(fēng)險(xiǎn)的關(guān)聯(lián)性。（剩余9280字）