外泌體在前列腺癌發(fā)生發(fā)展中的作用及在診斷方面的應(yīng)用前景
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Mechanism of exosome in the pathogenesis of prostate cancer and its potential diagnostic application
XUE Jingdong,WU Denglong
ABSTRACT:Prostate cancer (PCa) is one of the most common tumors in men.In recent years,various researches on this disease and clinical applications have benefited patients.Exosome is a subclass of extracellular vesicles (EVs).Many studies have explored the mechanisms of exosome in mediating epithelial mesenchymal transformation,angiogenesis,tumor microenvironment establishment,immune escape and drug resistance acquisition in PCa,which provides a new perspective for finding new diagnostic markers.This article reviews the role of exosome in the pathogenesis of PCa and its diagnostic application.
KEY WORDS:exosome;prostate cancer;tumor markers;tumor drug resistance;tumor microenvironment;cell to cell commu-nication;epithelial mesenchymal transformation
摘要:前列腺癌(PCa)是男性最常見的腫瘤之一,近年來隨著對其研究的深入和相應(yīng)臨床應(yīng)用的開展,患者也從臨床獲益。(剩余15950字)