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肝細胞癌靶向/免疫治療效果的預(yù)測指標

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摘要: 肝細胞癌(HCC)是我國常見惡性腫瘤,用于晚期HCC治療的分子靶向藥物和免疫檢查點抑制劑是當下的研究熱點,但治療效果存在較大的個體差異。為進一步篩選獲益人群,預(yù)測治療效果,改善疾病預(yù)后,本文對HCC靶向/免疫治療的效果預(yù)測相關(guān)研究進行總結(jié),為晚期HCC患者制訂個體化的治療方案提供參考。

關(guān)鍵詞: 癌, 肝細胞; 藥物療法; 免疫療法

基金項目: 國家自然科學基金(81870421)

Predictive indicators for the efficacy of targeted therapy/immunotherapy for hepatocellular carcinoma

REN Pengwei, HAN Ying, ZHOU Xinmin

Department of Gastroenterology, Xijing Hospital, Air Force Medical University, Xi’an 710032, China)

Corresponding author: ZHOU Xinmin, [email protected] (ORCID: 0000-0002-6521-9885)

Abstract: Hepatocellular carcinoma (HCC) is a common malignancy in China, and molecular-targeted drugs and immune checkpoint inhibitors for the treatment of advanced HCC are currently a research hotspot; however, there are large individual differences in the treatment outcome of advanced HCC. In order to further screen for the population with benefits from such treatment, predict treatment outcome, and improve disease prognosis, this article summarizes the studies on predicting the efficacy of targeted therapy/immunotherapy for HCC, so as to provide a reference for developing individualized treatment regimens for patients with advanced HCC.

Key words: Carcinoma, Hepatocellular; Drug Therapy; Immunotherapy

Research funding: National Natural Science Foundation of China (81870421)

肝細胞癌(HCC)是我國第4位常見惡性腫瘤和第2位腫瘤致死病因[1]。(剩余14143字)

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