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胰十二指腸切除術后胃排空延遲的發(fā)病機制及危險因素

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摘要:胃排空延遲(DGE)為胰十二指腸切除術(PD)后常見并發(fā)癥,其發(fā)病原因與機制目前國內外尚未完全闡明,但絕大多數(shù)患者可在一般對癥治療后痊愈。筆者對PD術后DGE發(fā)生的危險因素及病理生理機制進行綜述,旨在為臨床有效防治PD術后DGE提供參考。

關鍵詞:胰十二指腸切除術; 胃排空; 胃肌輕癱

基金項目:國家自然科學基金(U20A20360); 吉林省科技廳項目(20200603001SF)

Pathogenesis of delayed gastric emptying after pancreaticoduodenectomy and related risk factors

WANG Zhe, LYU Xing, YU Jiaao, SUN Xiaodong, LI Ting, LYU Guoyue. (First Department of Hepatopancreatobiliary Surgery, The First Hospital of Jilin University, Changchun 130021, China)

Corresponding author:LYU Guoyue, [email protected] (ORCID:0000-0002-9778-5080)

Abstract:Delayed gastric emptying (DGE) is a common complication after pancreaticoduodenectomy (PD). The etiology and pathogenesis of DGE have not been fully elucidated in China and globally, and the majority of patients can be cured after general symptomatic treatment. This article reviews the risk factors and pathophysiological mechanisms of DGE after PD, in order to provide a reference for the effective management of DGE after PD in clinical practice.

Key words:Pancreaticoduodenectomy; Gastric Emptying; Gastroparesis

Research funding:National Natural Science Foundation of China(U20A20360); Science and Technology Department of Jilin Province(20200603001SF)

胃排空延遲 (delayed gastric emptying, DGE)又稱為胃癱綜合征,為胰十二指腸切除術(pancreaticoduodenectomy, PD)術后常見并發(fā)癥之一[1],2007年國際胰腺外科學術委員會(ISGPS)[2]首次提出,可基于臨床癥狀的嚴重程度將DGE分為A、B、C三個等級,后兩級統(tǒng)稱為臨床相關性DGE,為臨床常用診斷標準。(剩余17207字)

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