SIRT1介導(dǎo)的信號(hào)通路在阿霉素誘導(dǎo)心臟毒性中的作用機(jī)制

【摘要】沉默信息調(diào)節(jié)因子1（SIRT1）通過介導(dǎo)多種信號(hào)通路參與調(diào)節(jié)氧化應(yīng)激、線粒體功能、細(xì)胞凋亡、炎癥反應(yīng)、內(nèi)質(zhì)網(wǎng)應(yīng)激、纖維化等病理生理過程，在阿霉素誘導(dǎo)的心臟毒性中發(fā)揮保護(hù)作用?，F(xiàn)總結(jié)SIRT1介導(dǎo)的信號(hào)通路在阿霉素誘導(dǎo)心臟毒性中的作用機(jī)制。

【關(guān)鍵詞】沉默信息調(diào)節(jié)因子1；信號(hào)通路；阿霉素；心臟毒性

【DOI】10.16806/j.cnki.issn.1004-3934.2024.03.015

The Mechanisms of SIRT1-Mediated Signal Pathway in Doxorubicin-Induced Cardiotoxicity

LI Dengke，ZHANG Wei，HUANG Congxin

（Department of Cardiology，Renmin Hospital of Wuhan University，Cardiovascular Research Institute，Wuhan University，Hubei Key Laboratory of Cardiology，Wuhan 430060，Hubei，China）

【Abstract】Silence information regulator 1（SIRT1） plays a protective role in doxorubicin-induced cardiotoxicity by mediating a variety of signaling pathways to participate in the regulation of oxidative stress，mitochondrial function，apoptosis，inflammatory response，endoplasmic reticulum stress，fibrosis and other pathological and physiological processes.This review summarizes the mechanisms of SIRT1-mediated signaling pathways in doxorubicin-induced cardiotoxicity.

【Keywords】Silence information regulator 1；Signal pathway；Doxorubicin；Cardiotoxicity

阿霉素（doxorubicin，DOX）是一種廣泛應(yīng)用的化療藥物，用于治療各種類型的癌癥，然而DOX的劑量依賴性心臟毒性極大地限制了其臨床應(yīng)用，最終導(dǎo)致不可逆的退行性心臟病和充血性心力衰竭［1］。（剩余11203字）