TCT檢測(cè)篩查ASCUS發(fā)生HSIL的高危因素分析

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[摘要] 目的 研究分析TCT檢測(cè)篩查不能明確意義的非典型鱗狀細(xì)胞（ASCUS）發(fā)生HSIL的高危因素。方法 回顧性分析2017年1月至2021年4月于廣東省汕頭市第三人民醫(yī)院婦產(chǎn)科經(jīng)TCT檢測(cè)篩查提示為ASCUS患者118例的臨床資料，分析ASCUS發(fā)生HSIL的高危因素。 結(jié)果 118例TCT診斷為ASCUS患者經(jīng)活檢病理金標(biāo)準(zhǔn)，其中炎癥改變27.97%（33/118）、LSIL56.78%（67/118）、HSIL15.25%（18/118），HR-HPV檢測(cè)HSIL的敏感度為88.89%（16/18），陰性預(yù)測(cè)值為97.18%（69/71）;研究組與對(duì)照組在首次性生活年齡、流產(chǎn)次數(shù)、HR-HPV及絕經(jīng)比較，差異有統(tǒng)計(jì)學(xué)意義（P

[關(guān)鍵詞] TCT;ASCUS;HSIL;高危因素

[中圖分類號(hào)] R711.74          [文獻(xiàn)標(biāo)識(shí)碼] B          [文章編號(hào)] 1673-9701（2022）12-0057-03

[Abstract] Objective To analyze the high risk factors of HSIL in atypical squamous cells （ASCUS） which cannot be clearly screened by TCT. Methods The clinical data of 118 ASCUS patients screened by TCT in the Department of Obstetrics and Gynecology in the Third People′s Hospital of Shantou City in Guangdong Province from January 2017 to April 2021 were analyzed retrospectively. The high risk factors of HSIL in ASCUS were analyzed. Results Among 118 patients diagnosed as ASCUS by TCT， taking biopsy pathology as the gold standard， patients with inflammatory changes accounted for 27.97% （33/118）， LSIL for 56.78% （67/118） and HSIL for 15.25% （18/118）. Patients who were detected by HR-HPV for the sensitivity of HSIL accounted for 88.89% （16/18）， and the negative predictive value was 97.18% （69/71）. There were significant differences in age of first sexual life， abortion times， HR-HPV and menopause between study group and control group （P

[Key words] TCT; ASCUS; HSIL; High risk factors

宮頸癌是女性惡性腫瘤發(fā)病率居第2位的腫瘤，據(jù)國(guó)際癌癥研究機(jī)構(gòu)2020年流調(diào)報(bào)道，我國(guó)新發(fā)病例約11萬(wàn)，死亡病例約6萬(wàn)，嚴(yán)重危害女性生命安全，因此，早篩早診早治控制宮頸癌發(fā)病率及死亡率至關(guān)重要[1]。（剩余5480字）