中藥山茱萸治療糖尿病腎病研究現(xiàn)狀

摘要：山茱萸為常用中藥材，補(bǔ)益肝腎，收澀固脫是其功效。山茱萸復(fù)方可以改善糖尿病腎病患者臨床癥狀，降低尿蛋白排泄、改善腎功能等；其作用機(jī)制包括抑制腎組織白介素6（IL-6）等多種炎癥因子分泌，抑制晚期糖基化終產(chǎn)物產(chǎn)生，減少腎小管上皮細(xì)胞中膽固醇積累，以及促進(jìn)腎組織一氧化氮合成等。

關(guān)鍵詞：山茱萸；糖尿病腎??；臨床研究；作用機(jī)制

中圖分類號(hào)：R692 文獻(xiàn)標(biāo)志碼：A 文章編號(hào)：1007-2349（2023）12-0076-04

Research Status of Cornus officinalis in Treating Diabetic Nephropathy

LI Pu-lin1， YANG Chen-hui1， XIE Shao-feng1， HUANG Li-ji2

（1. The Third Clinical School of Nanjing University of Traditional Chinese Medicine/The Integrative Chinese andWestern Medicine Hospital Affiliated to Nanjing University of Traditional Chinese Medicine， Nanjing 210028， China; 2. The Affiliated Hospital of Nanjing University of Traditional Chinese Medicine， Nanjing 210029， China）

【Abstract】Cornus officinalis is a commonly used Chinese herbal medicine and has the effect of tonifying liver and kidney. Cornus officinalis compound can improve the clinical symptoms of diabetic nephropathy patients， reduce urinary protein excretion， improve renal function and so on. Its mechanism of action includes inhibiting the secretion of various inflammatory factors such as interleukin-6 （IL-6） in renal tissue， inhibiting the production of advanced glycosylation end products， reducing the accumulation of cholesterol in renal tubular epithelial cells， and promoting the synthesis of nitric oxide in renal tissue.

【Key words】Cornus officinalis; Diabetic Nephropathy; Clinical Research; Action Mechanism

山茱萸屬于山茱萸科，補(bǔ)益肝腎，收澀固脫為其功效。（剩余5396字）