產(chǎn)后抑郁癥動物模型研究進展

[摘要] 近年來，產(chǎn)后抑郁癥發(fā)病率逐年上升，病因涉及多方面因素，發(fā)病機制未明。因此，建立可靠的動物模型能夠在產(chǎn)后抑郁癥發(fā)病機制研究、藥物新靶點發(fā)現(xiàn)及新藥研發(fā)中發(fā)揮重要作用。該文探討現(xiàn)有的產(chǎn)后抑郁癥動物模型，并從中獲得病機信息，以期為建立準確可靠、臨床實用的動物模型提供理論參考。

[關(guān)鍵詞] 產(chǎn)后抑郁；動物模型；綜述

[中圖分類號] R271.43          [文獻標識碼] A          [文章編號] 2096-1782（２０22）04（a）－０195-04

Research Progress on Animal Models of Postpartum Depression

LIU Xuan1， WU Xiaoqian2， YUAN Kewang1， LI Zhonglian1， SHU Kun1， AI Zhifu1， ZHANG Jie1

1. Jiangxi University of Traditional Chinese Medicine， Key Laboratory of TCM Syndrome Models for Depression， Jiangxi Administration of Traditional Chinese Medicine， Nanchang， Jiangxi Province，330006 China;2. School of Pharmacy， Jiangxi University of Traditional Chinese Medicine， Nanchang， Jiangxi Province，330006 China

[Abstract] In recent years， the incidence of postpartum depression has been increasing year by year. The etiology involves many factors， and the pathogenesis is unknown. Therefore， the establishment of reliable animal models can play an important role in the study of the pathogenesis of postpartum depression， the discovery of new drug targets， and the development of new drugs. This paper discusses the existing animal models of postpartum depression， and obtains the pathogenesis information from them， in order to provide a theoretical reference for the establishment of accurate， reliable and clinically practical animal models.

[Key words] Postpartum depression; Animal model; Review

20世紀20年代人們發(fā)現(xiàn)婦女在妊娠和產(chǎn)后期間會出現(xiàn)一些生理和心理變化，伴隨著情緒紊亂的病理變化[1]。（剩余7459字）