神經肌肉疾病患者睡眠呼吸障礙的診治進展

【摘要】 神經肌肉疾病易于合并睡眠呼吸障礙，早期診斷和干預睡眠呼吸障礙對慢性神經肌肉疾病的管理具有重要價值。本文回顧分析了神經肌肉疾病患者合并睡眠呼吸障礙的機制、臨床表現(xiàn)、診斷方法及治療進展。近年來雖然便攜式睡眠監(jiān)測設備不斷發(fā)展，但對此類患者的診斷價值尚未完全明確，仍需要更多的關注和研究。

【關鍵詞】 神經肌肉疾病；睡眠呼吸障礙；多導睡眠監(jiān)測；便攜式睡眠監(jiān)測；無創(chuàng)正壓通氣；診斷；治療

【中圖分類號】 R 746 R 563.8 【文獻標識碼】 Ａ DOI：10.12114/j.issn.1007-9572.2022.0266

丁啟迪，曹照龍，韓芳. 神經肌肉疾病患者睡眠呼吸障礙的診治進展［J］. 中國全科醫(yī)學，2022，25（33）：4203-4206 .［www.chinagp.net］

DING Q D，CAO Z L，HAN F. Advances in the diagnosis and treatment of sleep-disordered breathing in neuromuscular disease［J］. Chinese General Practice，2022，25（33）：4203-4206.

Advances in the Diagnosis and Treatment of Sleep-disordered Breathing in Neuromuscular Disease DING Qidi，CAO Zhaolong，HAN Fang*

Department of Respiratory and Critical Care Medicine，Peking University People's Hospital，Beijing 100044，China

*Corresponding author：HAN Fang，Professor，Chief physician；E-mail：[email protected]

【Abstract】 Sleep-disordered breathing（SDB） occurs frequently in neuromuscular disease（NMD） patients，and early diagnosis and treatment of which are of great value in the management of NMD. We reviewed the advances in pathogenesis，clinical manifestations，diagnostic and treatment modalities of SDB in NMD. It is noteworthy that although the development of portable sleep monitoring devices is ongoing，the diagnostic value of them for such patients has not been fully clarified，and more attention and further research are still needed.

【Key words】 Neuromuscular disease；Sleep-disordered breathing；Polysomnography；Portable monitor；Noninvasive positive pressure ventilation；Diagnosis；Treatment

神經肌肉疾?。╪euromuscular disease，NMD）是以神經肌肉功能受損、肌力減退、運動耐力下降為主要表現(xiàn)的一大類疾病，主要累及下運動神經元，如腦干運動神經元、脊髓前角、神經根、神經肌肉接頭、周圍神經等［1］。（剩余11369字）